No need for bulky temperature control hardware
Low power requirement enables battery operation and portability
Fast Reaction Times
10 -15 minutes vs the typical
1 - 2 hours for other technologies
Allows for economical deployment of multiple devices within a cultivation facility
The Opportunity for Growers
Actively track multiple diseases and isolate infected plants before contamination spreads and ruins product.
Pre-test plants to help save unnecessary fees for testing cultivated product that would fail.
Enable early discovery of Cannabinoid and Terpene profiles of plants to optimize the growth of favorable traits and the speed of developing new strains.
Remove males earlier to maximize the production of females and save on operational expenses.
Rapid, low-cost testing kits that, when coupled with an easy-to-use device, will enable non-scientist professionals to obtain nearly immediate on-location test results.
•Disease can spread to entire crops within days or even hours depending on factors such as wind and insects
•Track the spread to surrounding plants to remove infection early and greatly reduce the probability of large crop losses
•13% of all cannabis tested in the US failed initially in 2018 with an average cost of testing of $2.04/ounce = $295 million wasted on testing failed product
•Test throughout the growth phase of plants to enable proactive removal of unwanted pathogens or traces of pesticides
•Testing for cannabinoid and terpene profiles typically done near the end of cultivation
•Test plants within the first couple of weeks to find those with the highest potential
•Roughly 35% of all seeds produced are male plants that do not carry THC. Visual confirmation can take up to 4 weeks to determine the shape of the node
•Test plants as early as 1 week into cultivation to determine gender. Currently, roughly $650 million is spent in the US on inadvertent cultivation of male plants
Tinoro has developed a novel, non-thermal technology that uses electric fields to alter the pH distribution within a PCR solution. Cycling the pH level of the solution between nominal and more extreme values essentially has the same effect as traditional thermal cycling - except that it takes place on a much faster timescale.
The technology allows for a much lower device cost (an order of magnitude less than typical PCR instruments) as there is no need for bulky and expensive temperature control hardware. The cost per test is also relatively inexpensive since the technology enables the use of a very simple single-use consumable. Due to the low power level requirements to trigger the pH changes, our technology is compatible with a hand-held, battery operated device design.
Our proprietary analytics software platform can be used to empower end users in new ways. Use of the devices and associated analytics software in agricultural settings can help growers optimize conditions to maximize crop yield and quality.
Full scalability of the technology allows for simultaneous processing of multiple samples under different operating conditions.
Each sample in a consumable can be connected to the device via independent circuits.
Minimal additional power requirements are needed to run multiple amplification protocols simultaneously.
The ability to multiplex can significantly increase throughput for large sample test environments.
Tinoro has developed a disruptive, low-cost technology for DNA amplification using a new patented Polymerase Chain Reaction (PCR) method with the ability to quickly determine plant gender and to identify traces of pesticides, pathogens, mold, and more to maximize yield for cannabis growers.
Low cost, rapid gender and disease detection for cannabis production
Founded by entrepreneur Harel Hakakha and Analytics Ventures, a Venture Studio Fund, Tinoro is working to fill an unmet need in the cannabis cultivation industry. Driven by a mission to design and manufacture low-cost, intuitive, and easy-to-use devices, we aim to provide breakthrough PCR applications to growers around the World.
Our team consists of leading molecular biologists, biochemists, and general scientists that have been successfully developing intellectual property over the course of the last two years.
Mr. Hakakha has extensive biotech product development experience, including six years leading multiple new device development teams at Life Technologies. This is Mr. Hakakha’s third startup business, and his second as a founder. He has a strong working knowledge and understanding of new product development processes and the engineering and business challenges involved with the successful transfer of products from the concept stage to manufacturing and production. Mr. Hakakha holds BS and MS degrees in Mechanical Engineering from UCSD.
Mr. Roell is Managing Partner for Analytics Ventures, a San Diego focused early stage technology investment and formation venture capital firm. In this capacity, he is spearheading the group’s inception of new business ventures from strategy development, financing and launch. Currently under his direct leadership are ventures ranging from mobile technology, consumer solutions and big data advertising. An 18-year technology and advertising veteran, Mr. Roell currently serves on several board of directors, including KATANA, Kazuhm and the American Advertising Federation, the largest advertising trade association in the world.
Dr. Peterson has over 25 years experience in industrial research and development in the areas of molecular biology, nucleic acids and genomics product and technology development. His experience encompasses clinical diagnostics, life science research tools, and pharmaceutical discovery technologies and market segments. Dr. Peterson currently serves as CTO of Synthetic Genomics
Dr. Ekblom has over 20 years of experience in the life science sector. He has managed R&D programs in multiple fields of medical technology and in several therapeutic areas. Most recently, Jonas served as CEO of Bows Pharmaceuticals AG, a Swiss drug delivery company. Prior to that, he held senior management positions at Pharmacia, Biovitrum, Sequenom, and Thermo Fisher Scientific.
Dr. Lasken has spent much of his career studying DNA polymerases, the enzymes that synthesize DNA in the cell. His postdoctoral work was with Arthur Kornberg, Nobel Laureate, and discoverer of these enzymes. Dr. Lasken's team was the first to sequence genomic DNA from a single cell. He currently serves as Director of Single Cell Genomics at JCVI.
Dr. Romesberg is Professor of Chemistry at the Scripps Research Institute in San Diego, CA. His research interests are related to understanding and evolving novel protein function. Dr. Romesberg is the recipient of multiple academic awards, including the NSF Career Award in 2004, the Susan B. Komen Breast Cancer Foundation Award in 2003, the Dreyfus Teacher-Scholar Award in 2003, the Baxter Foundation Fellow Award in 2002, and the Mac Nevin Award in 1987.
Dr. Ortaç is the co-inventor of the non-thermal PCR technology licensed by Tinoro from UCSD. Inanc placed second in the UC San Diego Entrepreneur Challenge with a business plan for a medical device using this technology to enable rapid on-site detection of hospital-acquired infections. Subsequently he co-founded DevaCell Inc. and currently serves as the company’s chief technology officer. Dr. Ortaç is the author of several papers and holds 5 issued and pending patents. He holds MSEE and PhD degrees from UCSD.
Dr. Gong is an accomplished technical leader with a proven record of driving life science instrument development in the area of microfluidics. At Life Technologies he successfully designed and developed a novel digital PCR platform using electrowetting digital microfluidics and acoustic flow cytometry. While working as a principle engineer at Illumina, he performed the due diligence, feasibility studies, and R&D development of droplet based microfluidics for DNA sequencing. Jian currently works at Berkeley Lights, where he manages the technical development of a single cell genomic tool using novel opto-electrowetting technology. He holds a PhD degree from UCLA.
Dr. Ip provides scientific professional services to startups during the product development lifecycle. Using her background in biochemistry, molecular biology, and medical microbiology, she helps develop and refine products for launch or for ongoing R&D. Dr. Ip holds a PhD degree in Biochemistry and Molecular Biology from UCSB.
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